InGell LQP is our novel drug delivery depot platform. LQP stands for LiQuid Polymer, and that is exactly what it offers: a drug delivery depot that only consists of your API and our injectable, bio-erodable polymer.
We use the same polymer-technology as InGell Gamma, but with shorter tri-block co-polymers. This renders the pure polymer to be a thin liquid at ambient temperatures, injectable through up to 30G needles... No solvents involved!
LQP has the same safety, in-use and CMC benefits as the InGell Gamma system, but with the following additional features:
- Much longer retention and release of hydrophilic APIs such as proteins and peptides
- Excellent maintenance of bio-activity of peptides and proteins
- Stabilization of sensitive peptides
- Up to 10x higher loading capacity for solubilized hydrophobic small molecule drugs compared to the Gamma-system
The LQP-system is currently in development with customers in applications such as intra-articular drug delivery of small molecule API's and sub-cutaneous delivery of metabolic biologicals.
We also have collaborations on-going for slow release and localized delivery of proteins and vaccines in immuno-oncology.
I-LQP: these LQP-polymers have been end-capped with Iodine-units, making them visible in-situ under micro-CT. This offers safe and reliable opportunities for radiation therapy, positioning of solid tumours and visualisation of depots in-situ.