We create novel drug depot products using water-borne, bioabsorbable polymers, which can simply be mixed with drug compounds or other therapeutic actives. Upon injection into soft tissues, the polymers rapidly form a soft, macroscopic depot, which physically entraps the actives.

Thin needles and catheters can deliver the low viscous liquids in many different locations such as eyes, brain, joints, muscles and in other organs. Depot formation is instantaneous, while slow release of the drugs coincides with the progressing outside-in dissolution (erosion) of the depot. Basically, if the payload has been delivered, the depot is gone without a trace! This is ideal for repeat dosing strategies.

The release rate can be tuned to specific therapeutic applications by adjusting the molecular structure of the polymers used. The polymers are all based on well-known and safe-to-use building blocks for application in humans and animals. No organic solvents are part of the final product, simplifying registration, allowing combinations with sensitive biologicals, and overall greatly de-risking product development.  

Typical applications for InGell depots range from reducing side-effects and localization of novel therapies to life-cycle management opportunities. Total drug loading capacities are a magnitude higher than micro/nanoparticle-based systems, while also offering many CMC-related benefits.